Receptor Antagonist on Survival and Cardiac Function Increase in Endothelin-1 Production in the Heart and Beneficial Effect of Endothelin-A Role of Endothelin in Deterioration of Heart Failure Due to Cardiomyopathy in Hamsters
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چکیده
Rikako Yamauchi-Kohno, Takashi Miyauchi, Tomoko Hoshino, Tsutomu Kobayashi, Hajime Receptor Antagonist on Survival and Cardiac Function Increase in Endothelin-1 Production in the Heart and Beneficial Effect of Endothelin-A Role of Endothelin in Deterioration of Heart Failure Due to Cardiomyopathy in Hamsters : Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.99.16.2171 1999;99:2171-2176 Circulation. http://circ.ahajournals.org/content/99/16/2171 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin-A receptor antagonist on survival and cardiac function.
BACKGROUND We previously reported that chronic endothelin (ET) receptor blockade ameliorated the survival rate and cardiac hemodynamics in rats with chronic heart failure (CHF) due to myocardial infarction. However, it remains unclear whether ET-1 is involved in the pathophysiology of cardiomyopathy, which is one of the major causes of CHF. Accordingly, we investigated the production of ET-1 in...
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Objective(s): The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy. Results:In present study Endothelin treated car...
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Mitochondria play an important role in energy production for the cell. The proper function of a myocardial cell largely depends on the functional capacity of the mitochondria. Therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. Although originally designed for evaluating myocardial perfusion, 99mTc...
متن کاملDevelopmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)
Background: Broilers lung mechanisms that regulate endothelin (ET) in the lung are complex and poorly understood. Objectives: Methods: In this experiment lung ET-1 mRNA levels and lung mRNA expression for the ET(A) receptors were determined in lung tissue weekly (term = 42 days, intervals = 7 days). Serum endothelin concentration was also measured at these ages. Results: The study showed that e...
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تاریخ انتشار 1999